ur doctors whack, elevated creatinine levels in the blood is a result of creatine supplementation, especially if you had just loaded (although elevated levels do mean kidney probs, u just loaded). One study that was done in 2000, found it did have no effect on plasma levels, but that study did not involve any physical activity, so you can 86 that study.
latest study in 04 done in good Ol Canada!!
111: Muscle Nerve. 2004 Jan;29(1):51-8.
Creatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1.
Tarnopolsky M, Mahoney D, Thompson T, Naylor H, Doherty TJ.
Department of Medicine (Neurology and Rehabilitation), McMaster University,
Hamilton, Canada. tarnopol@mcmaster.ca
Creatine monohydrate (CrM) supplementation may increase strength in some typesof muscular dystrophy. A recent study in myotonic muscular dystrophy type 1(DM1) did not find a significant treatment effect, but measurements of muscle phosphocreatine (PCr) were not performed. We completed a randomized,double-blind, cross-over trial using 34 genetically confirmed adult DM1 patients without significant cognitive impairment. Participants received CrM (5 g,approximately 0.074 g/kg daily) and a placebo for each 4-month phase with a 6-week wash-out. Spirometry, manual muscle testing, quantitative isometric strength testing of handgrip, foot dorsiflexion, and knee extension, handgrip and foot dorsiflexion endurance, functional tasks, activity of daily living scales, body composition (total, bone, and fat-free mass), serum creatine kinase activity, serum creatinine concentration and clearance, and liver function tests were completed before and after each intervention, and muscle PCr/beta-adenosine triphosphate (ATP) ratios of the forearm flexor muscles were completed at the end of each phase.
CrM supplementation did not increase any of the outcome measurements except for plasma creatinine concentration (but not creatinine clearance). Thus, CrM supplementation at 5 g daily does not have any effects on muscle strength, body composition, or activities of daily living in patients with DM1, perhaps because of a failure of the supplementation to increase muscle PCr/beta-ATP content.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 14694498 [PubMed]
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Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations.
Schedel JM, Tanaka H, Kiyonaga A, Shindo M, Schutz Y.
Institute of Physiology, Faculty of Medicine, Lausanne University, Switzerland. Jean-Marc.Schedel@iphysiol.unil.ch
The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response to Cr ingestion a large rise in serum Cr concentration was observed (by 50 folds) occurring approximately 2 1/2h after the ingestion (peak value of 2.17 +/- 0.66 mmol x l(-1)).
We also found a moderate but significant rise in serum Crn concentration averaging 13 % after 3 h (peak value at 99.5 +/- 10.5 micromol x l(-1)). A dose response curve obtained in two case studies, in whom different doses of Cr were ingested (0, 2.5, 5, 10, 15, 20 g and 0, 10, 20, 30 g), showed that serum Cr concentration as well as the peak time increased linearly with Cr ingestion. In addition, acute Crn ingestion (5 g) resulted in a substantial increase in serum Crn concentration (by 10 folds) but led to a minor rise in serum Cr concentration (by 2 folds). These results suggest that when acute doses of Cr are ingested in humans, the degree of conversion of exogenous Cr to Crn in the stomach and the gut can be considered as negligible following the first 6 h of ingestion. However, further studies are required to explore the prolonged effect of Cr on Crn metabolism.
PMID: 10622230 [PubMed - indexed for MEDLINE]