Here is a study showing nolva blocks the suppresive nature of HCG..
Tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone accumulation in normal men.Smals AG, Pieters GF, Drayer JI, Boers GH, Benraad TJ, Kloppenborg PW.
Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.
PMID: 7419679 [PubMed - indexed for MEDLINE]
Related ArticlesDifferential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization. [J Clin Endocrinol Metab. 1984] Enhancement of gonadotrophin induced 17,20-lyase suppression one week after human chorionic gonadotrophin priming. [Acta Endocrinol (Copenh). 1982] Dissociated responses of plasma testosterone and 17-hydroxyprogesterone to single or repeated human chorionic gonadotropin administration in normal men. [J Clin Endocrinol Metab. 1980] Testicular steroidogenesis in adult men with human chorionic gonadotropin-producing tumors. [J Clin Endocrinol Metab. 1995] Lack of a biphasic steroid response to single human chorionic gonadotropin administration in patients with isolated gonadotropin deficiency. [J Clin Endocrinol Metab. 1980] » See all Related Articles...
Merc.
|