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Old 05-09-2008, 01:54 PM
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Just don't buy into the rule that if 1 mg is good then 2 mg's are better. Dostinex has some great side effects making johnanthony jr a happy boy. I know some guys are taking it daily and at doses as low as 2mg's it can cause problems with the cardiac valves. 1 mg twice a week is well within the safe range. I run dostinex from the onset of a cycle with deca and get away with the lower dose. If you're holding off and waiting until you notice signs of prolactin then a larger dose up to 1.5 mg's can be used and works very quickly. Here's a little bit from the FDA on dostinex.

Pharmacodynamics
Dose response with inhibition of plasma prolactin, onset of maximal effect, and duration of effect has been documented following single cabergoline doses to healthy volunteers (0.05 to 1.5 mg) and hyperprolactinemic patients (0.3 to 1 mg). In volunteers, prolactin inhibition was evident at doses >0.2 mg, while doses ≥0.5 mg caused maximal suppression in most subjects. Higher doses produce prolactin suppression in a greater proportion of subjects and with an earlier onset and longer duration of action. In 12 healthy volunteers, 0.5, 1, and 1.5 mg doses resulted in complete prolactin inhibition, with a maximum effect within 3 hours in 92% to 100% of subjects after the 1 and 1.5 mg doses compared with 50% of subjects after the 0.5 mg dose.

In hyperprolactinemic patients (N=51), the maximal prolactin decrease after a 0.6 mg single dose of cabergoline was comparable to 2.5 mg bromocriptine; however, the duration of effect was markedly longer (14 days vs. 24 hours). The time to maximal effect was shorter for bromocriptine than cabergoline (6 hours vs. 48 hours).

In 72 healthy volunteers, single or multiple doses (up to 2 mg) of cabergoline resulted in selective inhibition of prolactin with no apparent effect on other anterior pituitary hormones (GH, FSH, LH, ACTH, and TSH) or cortisol.

Last edited by hazcat : 05-09-2008 at 02:00 PM.
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