This is from DatBtrue who if you read his posts can't help but impress. I take his opinion on peptides as gospel because he is far more experienced and well read than I.
Okay, if you have been reading me for years you would know I have a huge bias against IGF-1 and that instead of just being negative I dug up a lot of research concerning it over the last 18 months on PM and in my now deleted 2nd thread at AM and posted many different angles. I am my own best devils advocate.
My position has consistently been GH & the GHRH/GHRPs create all of the local IGF-1 & MGF that you will need in muscle and that when they go and draw blood plasma and measure circulating IGF-1 (i.e. endocrine liver-made) the reading is of limited value. What is important is IGF-1 and MGF actually created in muscle where it will be used. Currently they have no way to test that in a medical setting.
I believe I have pointed to GH & testosterone increasing local production of IGF-1 & MGF and that adding IGF-1 to this mix, at least in vitro completely abolished the increase.
I believe I have said that taking exogenous IGF-1 PWO was THE EXACT WRONG time to take it. IGF-1 will act to differentiate newly formed "cells", but what you want post-workout is the production or proliferation of undefined cells. MGF is expressed PWO naturally and it is responsible for proliferation. So adding IGF-1 right when MGF gets going cuts proliferation short.
Its like starting a battle by assigning weapons to the first 10 guys that show up and then mounting a charge. It is much better to sit and wait until 10 guys then 50 guys then 500 guys show up before assigning them duties and starting the battle. 500 guys always make a bigger impact then 10.
Back a year ago I talked about IGF-1 LR3 not staying local when injected unless it was prebound to the other two components of the tertiary complex (IGFBP3 + acid labile subunit +IGF-1).
I have spent some time w/ a guy named Clarity&Focus trying to see how much IGF-1 is lost because there is no Human or Bovine Serum Albumin added and because many IGF-1 sellers don't have the correct amount of buffer added which will work well when acetic acid is added. Instead often there is no buffer and acetic acid just degrades the peptide. We discovered that a significant maybe 40% of the IGF-1 was lost due to adhering to the glass of the vial. That is what HSA or BSA is for but since it s a blood product it is very difficult to obtain and ship across borders.
I have said a great deal about IGF-1 over the years... including the fact that the healing properties only require 1/300th of the dose needed to be systemically anabolic.
I think IGF-1 LR3 works extremely well for healing via injection near the injury (multiple times) or internally to heal the gastrointestinal tract... I have never been a big fan of IGF-1 anabolically.
Having said all of that I do have posts on trying to make IGF-1 at least have some measurable local activity. That is where the multi-dosing micro dosing protocol comes into play. In addition timing should be as far away from the workout event as possible in the muscle just worked. At night the night before a workout is a good time.
I gave up on IGF-1 for anabolism in my own body years ago in favor of GHRH/GHRPs.
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