Estrogen and AI's will it effect your gains ??

[martyrobbins]

Originally Posted by access

Merc please post up more often.. these are good posts that lead to intersting debate!

Agreed!!!

Thanks Merc

[Merc.]

Originally Posted by martyrobbins

Agreed!!!

Thanks Merc

Thank you ..






Merc.

[Merc.]

Also alot of peeps ask about using nolva... Nolva can also reduce gains .. It lowers IGF-1.

Here is one interesting study that about nolva lowering IGF-1 .. There are quite a few studies on this ) ...

Tamoxifen reduces serum insulin-like growth factor I (IGF-I).Pollak MN, Huynh HT, Lefebvre SP.
McGill University, Montreal, Quebec, Canada.

Antiestrogens are widely used in the management of hormonally responsive breast cancer in both adjuvant and palliative settings, and are currently being evaluated as chemopreventive agents. The classical mechanism of action of these drugs involves inhibition of estrogen-stimulated neoplastic cell proliferation by blockade of estrogen receptors present on breast cancer cells. This paper reviews recent clinical and laboratory data that suggest that the commonly used antiestrogen tamoxifen also acts to reduce serum IGF-I levels. Estrogens appear to play a permissive role in growth hormone (GH) release by the pituitary gland and GH is known to stimulate IGF-I expression by hepatocytes. It is therefore possible that blockade of estrogen receptors in the hypothalamic-pituitary axis by tamoxifen interferes with GH release, leading to reduced hepatic IGF-I expression. In view of results suggesting that IGF-I is a more potent mitogen than estradiol for breast cancer cells and data demonstrating a positive correlation between estrogen receptor level and IGF-I receptor level of breast cancer cells, the IGF-I lowering effect of tamoxifen may contribute to the cytostatic activity of the drug. The interrelationships between steroid hormone physiology and IGF-I physiology may have relevance to a variety of commonly used treatments for hormonally responsive cancers.

PMID: 1421427 [PubMed - indexed for MEDLINE]

Related ArticlesEffect of tamoxifen on serum insulinlike growth factor I levels in stage I breast cancer patients. [J Natl Cancer Inst. 1990] Effect of tamoxifen on GH and IGF-1 serum level in stage I-II breast cancer patients. [Anticancer Res. 2001] Induction of insulin-like growth factor binding protein expression by ICI 182,780 in a tamoxifen-resistant human breast cancer cell line. [Breast Cancer Res Treat. 1999] Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells. [Cancer Res. 1997] In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen. [Cancer Res. 1993] » See all Related Articles...


Merc.

[Merc.]

It seems a lot of peeps are taking AI's when they aren't really needed.. So many people only talk about the negative effects of estrogen .. So many people look at estrogen as evil because all they read are the negative effects ... It is very important to understand estrogen's role in the muscle building process..

Merc.

[h4x0l2]

so according to the reading, PCT should only be used if you are experiencing negative side effects of the estrogen?

[Merc.]

Originally Posted by h4x0l2

so according to the reading, PCT should only be used if you are experiencing negative side effects of the estrogen?

No .. Nothing to do with PCT ... Talking about using them [AI's]while on cycle..



Merc.

[h4x0l2]

Originally Posted by Merc.

No .. Nothing to do with PCT ... Talking about using them [AI's]while on cycle..



Merc.

ooooh gotcha ok, got lil confused there =)

[Merc.]

Originally Posted by h4x0l2

ooooh gotcha ok, got lil confused there =)

No problem .. If you have any questions or thoughts post em up .....



Merc.

[whytee]

So im geussing , well more like asking is it better to wait a bit to see how you react to cycle rather then start a small dosing of an AI.

[advanced-stealth-rep]

Good info...