HCG Information

[Smiley]

Taken from the Supersite.

HCG

Chemical Name: Human Chorionic Gonadotropin
Drug Class: Gonadotropin

Human Chorionic Gonadotropin is a substance that, in the human body, mimics Leutenizing Hormone (LH). LH is secreted by your body, and its secretion then signals the body to begin releasing testosterone.

HCG is typically employed by steroid-using athletes to bring back some naturally produced testosterone into their bodies. However, HCG is clinically used both to induce ovulation and treat certain ovarian disorders in women. In men is utilized to stimulate the testes in hypogonadal men (men who are not producing testosterone). It has also shown promise in the treatment of undescended testicles in young males.

The action of HCG in males is very similar to that of LH, because they are chemically similar and since LH binds to receptors on human Leydig cells, we see a similar mechanism of action with HCG. Once it binds and begins to stimulate the receptors on the Leydig cells, it begins to trigger the synthesis and secretion of testosterone. However, HCG will only send an “artificial” signal to the testes through Leydig cell stimulation. Thus, it is possible that HCG use can cause Leydig cell desensitization. I don’t know of anyone who has actually experienced this, nor who has even claimed that it’s happened to either them or a friend, or whatever- anecdotal evidence here is scarce.

However, there are two schools of thought regarding HCG use, and neither are very new. In fact, both have been around since the earliest books on underground steroid use, and were spoken about more than a decade ago by Dan Duchaine (Underground Steroid Handbook) and also by W. Nathaniel Phillips (Anabolic Reference Guide volumes 1-6). The latter author, by the way is actually Bill Phillips, the author of Body for Life, and the former owner of both Muscle Media and EAS (ok, so that was a bit off track…). Anyway, let’s talk about those two uses for HCG…

When used on a cycle sparingly, HCG helps to maintain testicular size and condition but it is speculated that the intermittent administration of HCG will keep the testicles receptive to LH, when we eventually go off a cycle. This may be due to HCG’s ability to maintain of a higher level of Inter-Testicular-Testosterone (ITT), when used during a cycle. This could aid and quicken your recovery of the hypothalamic-testicular-pituitary-axis. This is certainly possible. When used after a cycle, it will still help in restoring your testicles back to their original size, and provide stimulation for the Leydig cells. Both methods have merit, and there’s no reason why you can’t use HCG every third week at a one time dose (perhaps) 500iu or so, and then use it at that same dose for a daily schedule at the outset of your Post Cycle Therapy.

Interestingly, one study I looked at showed that by using Vitamin E along with HCG, a greater blood plasma testosterone elevation. This tells me that we should always be loading up on some Vitamin E the day we’re shooting our HCG- 1,000iu of Vitamin E should be plenty. Another welcome addition to use of HCG is Nolvadex. Using Nolvadex in conjunction with HCG seems to make the chance of any inhibition of the HPTA very unlikely.

As HCG is used to stimulate testosterone production, theoretically, side effects could be the same as those associated with Anabolic Steroids, although gynocomastia (development of breast tissue in males) seems to be the most probable, though still uncommon.

[Merc.]

Good post Smiley

Yep it is good to use nolva when using HCG ( in post cycle) .. HCG is suppressive.. blocks the conversion of 17 OHP to test... Using nolva in conjunction with HCG blocks its suppressive nature ..

Also -- like Anthony Roberts advises in his pct protocol- adding an AI like aromasin .. Any suppression form the estrogen engendered by the HCG is going to be halted with the aromasin ..

Merc.

[Merc.]

Here is a study showing nolva blocks the suppresive nature of HCG..

Tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone accumulation in normal men.Smals AG, Pieters GF, Drayer JI, Boers GH, Benraad TJ, Kloppenborg PW.
Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.

PMID: 7419679 [PubMed - indexed for MEDLINE]

Related ArticlesDifferential effect of single high dose and divided small dose administration of human chorionic gonadotropin on Leydig cell steroidogenic desensitization. [J Clin Endocrinol Metab. 1984] Enhancement of gonadotrophin induced 17,20-lyase suppression one week after human chorionic gonadotrophin priming. [Acta Endocrinol (Copenh). 1982] Dissociated responses of plasma testosterone and 17-hydroxyprogesterone to single or repeated human chorionic gonadotropin administration in normal men. [J Clin Endocrinol Metab. 1980] Testicular steroidogenesis in adult men with human chorionic gonadotropin-producing tumors. [J Clin Endocrinol Metab. 1995] Lack of a biphasic steroid response to single human chorionic gonadotropin administration in patients with isolated gonadotropin deficiency. [J Clin Endocrinol Metab. 1980] » See all Related Articles...


Merc.

[willy222]

does HCG need to be stored in the fridge?

[Merc.]

Originally Posted by willy222

does HCG need to be stored in the fridge?

Yes.. After you mix it ......




Merc.

[Smiley]

No I think it comes to you in a powder with sterile water to add to it. Maybe when mixed it does? Normally 5000iu in a bottle of powder.

[Smiley]

Also there are cases of people developing gyno when using HCG because of the large increase in test production so that needs to be made clear and managed. I think it is fairly rear but possible non the less.

[Merc.]

Originally Posted by Smiley

No I think it comes to you in a powder with sterile water to add to it. Maybe when mixed it does? Normally 5000iu in a bottle of powder.

Yes it comes in a powder ( and you add bac water ) after you reconstitute it ( mix it ) it should be refrigerated ... And it is good for 30 days ..



Merc.

[Merc.]

Bumper ...


Merc.

[eddgardd]

is it pregnile the hcg or its diffrent cus i use to take pregnile 5000 for 3 weeks after 3 weeks from the cycle i get it from the pharm