More Insulin Info

[stk]

Thanks DTD - aka "monkey crackin coconuts"

Big Fat Bastards and Insulin
by Author L. Rea



Publication Date: August 28, 2002
Nothing in this article is intended to take the place of advice from a
licensed
health professional. Consult a physician before taking any medication.

Ask any of the elite who has become truly massive beasts which anabolic
substance has had the most profound effect upon their physique and the
answer
from the largest mammals will unanimously be insulin. Though GH has brought
to
the forefront of competitive stages the well retained lean muscle mass
tissue
displayed beneath an onion skin exterior of today, it is the symbiotic
relationship insulin has with all other physical enhancement chemistry that
has
made beasts what they are in the new millennium.

Insulin is predominantly a storage hormone in that it initiates a cascade of
cellular events that result in up-regulation of cellular nutrient content.
It
obviously goes without saying then that supraphysiological plasma levels of
insulin result in supraphysiological cellular levels of nutrients. This in
itself allows for a highly anabolic effect known as an osmotic response. A
cellular osmotic response is nothing more than an increase in water and
growth
potentiating nutrients intracellularly that has an effect similar to
increasing
the amount of air in a balloon. More air in the balloon means a larger
balloon.
More water and proportionate growth nutrients means a larger cell.
Interesting
enough is the fact that this also triggers another survival mechanism that
tells
the stretched cell wall to increase in thickness to accommodate the osmotic
response. This is due to an up-regulation in localized IGF-1 and MGF
production
and the synergistic response initialize. Oh ya. That is anabolism in the
form of
hypertrophy. Unfortunately, insulin is quite anabolic to fat cells too.

Since insulin is the body’s main "storage" hormone it should come as no
surprise
to the reader that many diabetics and would-be beasts alike have become
horribly
fat as a result of improper insulin use and misguided dietary habits. Many
bodybuilders have employed the 10-15 grams of carbohydrates per IU of
insulin-administered protocol with a great deal of success in spite of the
inherent dangers of non-medical insulin use. However many, who have either
become insulin resistant/insensitive or are genetically predisposed to
inordinate adipose (fat) tissue accumulation, have endured a greater
anabolism
of adipose tissue than muscle. Some have foolishly put on more covering
clothing
and simply accepted this as a necessary side effect endured for the greater
eventual goal. Others have added the additional potential negative side
effects
of heart arrhythmia/tachycardia, diabetes, and other not so fun stuff as
well.

As I have pointed out many times before, adipose tissue is a major site for
aromatase enzyme activity, which in itself compounds the Big Fat Bastard
problem. Many AAS (anabolic/androgenic steroids) are susceptible to the
effects
of aromatase enzyme conversion to estrogens as is endogenously produced
(made
inside the body) androgens such as testosterone. Obviously the greater the
volume and activity of this enzyme that exists in the body, the greater the
chance and degree of aromatization that occurs. Estrogen is directly
anabolic to
a minor degree to muscle tissue. Both fortunately and unfortunately it is
highly
anabolic to adipose tissue. Since estrogen is the hormone that induces
female
pattern fat deposits it is fortunate because a nice rack is a thing of
beauty.
Unfortunately I have as of yet not noted a single male bodybuilder who
looked
good or happy with boobs or any other fatty female attributes. So a greater
degree of adipose tissue accumulation from insulin administration results in
a
compounded adipose tissue storage effect from aromatase enzyme susceptible
AAS
employment.

In some instances the result of this vicious cycle is bodybuilders who fail
to
ingest adequate calories during AAS protocols as a means of decreasing
adipose
tissue accumulation. Unless you are from another planet you realize this
also
limits muscular growth potential as well.

Before we discuss all of the interesting facts concerning the means of
becoming
a big fat bastard, it is necessary to have a fundamental understanding of
the
macronutrient product glucose.


GLUCOSE

Glucose is the body’s preferred energy substrate. Though the brain’s
nutrient
make-up is nearly 1/3 omega-3 fatty acids it is glucose that is without fail
mandatory for continued sentience. So carb up a little and read closely as
we
learn a few things about the body we have been entrusted to play nice with.
When we ingest food stuffs in the form of the three macronutrients protein,
carbohydrates, and fats the GI track introduces a series of chemical
Action/Reaction Factors that result in the break-down of these nutrients to
metabolic substrates.

Proteins = amino acids
Carbohydrates = glucose
Fats = fatty acids

It appears simple on the surface but in fact glucose can be converted to
triglycerides and adipose tissue or lean tissue glycogen stores and toilet
tinkle. Like wise fatty acids can be stored as fat or utilized as an energy
substrate by the body’s tissues but it cannot be converted to glucose. This
is
interesting when one considers the fact that carbohydrates can become
glucose or
fat, but fat cannot become glucose (though the cellular mitochondria can use
fatty acids as an energy substrate as a keto response). Protein is
ultimately
destined to become amino acids employed for cellular repair and growth or
intimate moments with the bathroom. But certain amino acids called
gluconeogenic
amino acids can be converted to glucose too. This can be disastrous for a
bodybuilder who hopes to be a beast one day since lean muscle mass is
predominantly made up of protein in the form of amino acids and a complete
spectrum is necessary. We will get to this later. For now simply accept that
glucose is necessary for life and bodybuilding progress alike.

The average circulatory value for glucose allows for about only 4 grams of
glucose. It is actually uncommon for blood glucose levels to rise beyond an
additional 1.5-2.0 grams or to drop below the 4 gram mark. A healthy
individual
who ingests a meal containing 50-150g of mixed carbohydrates will realize
the
normal increase in circulatory glucose for only about an hour. Interesting
thing
here is that endogenous (made by the body) insulin secretion will remain
elevated for an additional 2 hours after glucose clearing. When the same
individual ingests 300g of carbs (Fat Bastard) at one time the resulting
insulin
secretion levels will be 300% above normal for an additional 7 hours after
blood
glucose clearing. This is clearly a highly anabolic environment, but after
tissue glycogen stores reach maximum levels a grotesque amount of the excess
glucose finds its way to adipose tissue. And don’t worry. If all of the
existing
fat cells are full, the body is way to happy to make new ones to secrete
lots of
aromatase enzyme. And herein awaits the key to greater lean mass tissue and
a
decrease in adipose tissue.

GLUCONEOGENESIS

Gluconeogenesis is the biosynthesis of new glucose. This means that glucose
is
synthesized from other substrates than carbohydrates or glycogen stores.
Obviously since the only source of fuel for the brain, testes, kidneys, and
erythrocytes is glucose the body in its amazing adaptive manner can
manufacture
glucose from other materials. Those who are up on keto diets are aware of
the
fact that the body can derive energy from ketone bodies (which are converted
into acetyl-CoA). But that is an entire different topic for now. In short
the
body utilizes the carbon structures within substrates to create energy in
the
eventual form of ATP (adenosine triphosphate). ATP is cellular energy that,
as
readers are aware, is the body’s only energy currency. In the case of
gluconeogenesis the carbon structures can come from other sources.
Triglycerides are structures consisting of three fatty acids adjoined by a
glycerol molecule. By cleaving the fatty acids away from the glycerol
molecule
the body can utilize the freed glycerol molecule to make glucose through a
series of conversions and subsequent carbon utilization.

With the exception of lysine and leucine all 20 (or 22 if you are of that
school
of thought) amino acids can be turned into TCA cycle intermediates which in
turn
allows for the carbon skeletons of the amino acids to be converted to
pyruvate.
The newly formed pyruvate can then be utilized by the gluconeogenic pathway
to
create glucose by way of another series of metabolic pathways. Let me
explain
that a little better. When glycogen stores in the liver and muscle are
depleted
the working/recovering muscles, brain and organs need another energy source.
Catabolism of muscle tissue proteins to amino acids becomes the main source
of
carbon skeletons for the maintenance of mandatory blood glucose. As you will
recall the body can clear 50-150 grams of carbohydrates in only a few hours.
So how much muscle do you think the gluconeogenic adaptive process can munch
in
the same period of inadequate nutrient supply from diet? By the way, the
amino
acid Alanine is the favorite gluconeogenic snack with Arginine and Glutamine
coming in as close seconds.

THINK ABOUT IT

In the presence of circulatory insulin elevation gluconeogenesis in the
liver
and muscle tissue decreases. During periods of circulating
supraphysiological
levels of amino acid muscle catabolism decreases. In the presence of both
protein synthesis occurs.

So it would seem that the two choices a wanna-be beast faces is 300 grams of
carbohydrates to induce a sufficient prolonged insulin spike and a Big Fat
Bastard pose down or non-stop keto diets and declarations of "Hey, I may
look
like a weenie but I am really cut" for life.

The obvious solution is an elevation in both circulatory insulin and a
corrected amino acid pool rendered highly efficient by design and not by
chance.

Insulin administration is nothing new to the larger beasts of the
bodybuilding
world. Unfortunately neither is Big Fat Bastard status in the brief
off-season.
So it should come as no surprise to those who have entered the realm of the
chemically enhance athlete to learn that insulin can make even the best
genetically predisposed individual fat. It has been my experience that this
is
simply not necessary.

Insulin forces excessive amounts of amino acids into muscle cells when an
adequate supply exists at the time of insulin exposure. Insulin also
triggers
increased muscle cell glycogen synthesis by way of positively effecting the
rate
limiting enzyme glycogen synthase. We also know the positive effects correct
application of supraphysiological insulin levels has had upon the most
catabolic
pathway there is that affects muscle mass from reading my two prior books.
Add
to this the fact that insulin is synergistic to and with all other chemicals
of
muscular enhancement and realize the potential.

In relationship to goals it would seem evident that a protocol employing the
attributes of insulin would necessitate the symbiotic relationship the
hormone
has with macronutrients as it applies to lean muscle mass tissue.

Muscle is more than 80% protein by dry weight.

ATP is the energy currency of muscular contractions, repair, and growth.

Glucose is the prime source substrate for ATP synthesis and mandatory for
proper brain and organ function (yes, that one also).

Excess blood glucose will result in excess adipose tissue accumulation.


The Protocol

Diet

When this protocol was created its intent was rapid accumulation of lean
mass
tissue without an increase in adipose tissue deposits. Since the foundation
of
the diet was structured for efficient gluconeogenic dependant upon a correct
ratio and amount of amino acids, a great deal of protein was consumed daily.
The
most effective protein intake minimum was the equivalent of 3 grams of
protein
per pound of bodyweight daily divided into at least 6 meals. Using a 200
pound
individual as an example it was possible to reduce this slightly by simply
eating 4 whole food meals daily providing 50 grams of whole protein each and
sipping on whey protein drinks in water throughout the day
providing the remaining 400 grams of protein. I preferred whey protein
simply
because it is one of the only two drinkable products I am aware of that
allows
for actual hyperaminoacid response in the circulatory system. Casein, egg,
and
(some people still use it) soy proteins fail to clear the GI track at a rate
significant enough to induce the necessary supraphysiological amino acid
concentrations for the protocol. The fact that whey protein is easily
oxidized
by the liver should be the first clue to the reason why results are
superior. By
the way, the other is Human Profile by Hazardous Materials (it is nearly
100%
absorbed)

So here is the kicker. Though fat intake could be quite high, total daily
carbohydrate intake could not exceed 0.5 grams per 25 pounds of bodyweight
daily. The reason is simple: The goal was to force the body to employ the
gluconeogenic pathway as a means of energy production. Any degree of actual
glycogen regeneration resulted in the body returning to the glycosis pathway
which allows for adipose tissue accumulation. The reason this worked so well
was
simplistic in nature. The making of ATP through amino acid gluconeogenesis
is
very inefficient thus allowing for a huge calorie expenditure similar to
what
occurs during DNP utilization. During calorie expenditure the body does not
store fat but it does undergo protein anabolism. When enough protein was
ingested the result was always a net increase in lean body mass of 5-8
pounds by
the end of a two week protocol. Not bad for an experienced beasts, huh?


Additional Supplements

Since exogenous insulin was utilized during this protocol and, as mentioned
prior, the gluconeogenic energy pathway loves certain amino acids it is easy
to
realize that the normal ratio of amino acids derived from whey protein and
whole
foods was not likely adequate. A mixture of 4 parts Alanine, 2 parts
Glutamine,
2 parts Arginine and 1 part Taurine was created and capsulated. The dosage
ingested was 1 gram of the supplemental mix per I.U. of insulin administered
daily divided into 2 post administration dosages.

The preparation for this protocol required a liver glycogen depletion period
of
24 hours prior to initial insulin administration. This was done to initiate
the
gluconeogenic pathway prior to protocol onset thus preventing any loss of
lean
tissue growth potential.
Though only a total idiot would ever assume that non-medical exogenous
insulin
use was safe, the utilization of a fast acting insulin was the better choice
for
this protocol. The first reason of course being that short acting chemistry
also
means shorter periods of potential exposure to negative side effects like a
coma. Second is the fact that it was necessary due to the relevance in liver
capacity for glucose manufacture by way of gluconeogenesis. Running out of
adequate glucose reserves would introduce a series of potential negative
side
effects that would have required the ingestion of dextrose to inhibit.
EXAMPLES OF INSULIN
Name of InsulinStart ActivityHighest ActivityEnds ActivityLow BS
Very short-acting (Humalog) 10 minutes1.5 hours3 hours2-4 hours
Short-acting (Regular/-R)20 minutes3-4 hours8 hours3-7 hours
Intermediate acting (Nor L)1.5-2 hours4-15 hours22-24 hours6-13 hours
Long-acting (Ultra Lente)4 hours10-24 hours36 hours12-28 hours
Combination: 70% N/30% R0-1 hour3-13 hours12-20 hours3-12 hours
Combination: 50% N/50% R0-1 hour3-12 hours12-20 hours3-12 hours

Humalog was administered about 15 minutes before an appropriate meal
Regular Type-R was administered 30 minutes before an appropriate meal
Low BS = Low blood sugar (Glucose).
As the reader can see when viewing the examples of insulin above, the
employment
of Humalog allowed for a total of 4 daily administrations of 10-15iu each
and
Humulin-R (Short-acting) only allowed for 3 daily administrations. This is
not
to say some have not increased the dosage or chose different insulin
analogs,
but it is to say that under these circumstances it was not necessary or more
effective.
When looking at the following example consider these facts:
Testosterone suspension has an active-life of about 24 hours tough plasma
androgen levels remain elevated for about an additional 24 hours.
Sex hormones such as testosterone and estrogens are inactive when bound by
SHBG (sex hormone binding globulin) and free or active when not.
Insulin is a powerful SHBG inhibitor.
Insulin increases muscle glucose transporters and androgen receptors

Protocol Example
Day Protocol Day Protocol
1.Testosterone Sus. 150mg 15.Testosterone Sus. 150mg
2.Humalog 10iu 4xd 16.Humalog 10iu 4xd
3.Testosterone Sus. 150mg 17.Testosterone Sus. 150mg
4.Humalog 10iu 4xd 18.Humalog 10iu 4xd
5.Testosterone Sus. 150mg 19.Testosterone Sus. 150mg
6.Humalog 10iu 4xd 20.Humalog 10iu 4xd
7.Testosterone Sus. 150mg 21.Testosterone Sus. 150mg
8.Humalog 10iu 4xd 22.Humalog 10iu 4xd
9.Testosterone Sus. 150mg 23.Testosterone Sus. 150mg
10.Humalog 10iu 4xd 24.Humalog 10iu 4xd
11.Testosterone Sus. 150mg 25.Testosterone Sus. 150mg
12.Humalog 10iu 4xd 26.Humalog 10iu 4xd
13.Testosterone Sus. 150mg 27.Testosterone Sus. 150mg
14.Humalog 10iu 4xd 28.Humalog 10iu 4xd

Testosterone Sus. = testosterone suspension

150mg of testosterone suspension created a great deal of estrogen since it
originates as a non-esterfied AAS. Estrogen up-regulated the muscle cells
glucose transporters called GLUT-4 and increased androgen receptor
sensitivity.
This also meant that the administered testosterone was free or unbound from
its
inactivating protein SHBG. A great deal of the hormone entering the
circulatory
system was quickly bound, though not before a serious degree of anabolism
occurred. But there is a portion left bound and in reserve.
Insulin inhibited SHBG resulting in a synergistic pro-anabolic response. By
freeing the remaining prior days administered testosterone from SHBG an
increase
in androgenic activity was realized. Since SHBG is also estrogens binding
protein the excretion of estrogens was dramatically accelerated. This
resulted
in rapid estrogen clearing and a notable increase in GH secretion which was
amplified by the lack of the inhibitory effect normally caused by excess
glucose. As most readers are aware, GH and insulin must both be present in
the
liver to produce IGF-1.

The end result was adequate glucose regeneration at the expense of adipose
tissue with a profound degree of lean tissue protein synthesis and growth.
No
more Big Fat Bastard!


BLOODLINE-Disclaimer:

STK is presenting fictional opinions and doesnt in any way, shape or form encourage, use, nor condone the use of any illegal substances in an unlawful manner. The information discussed is strictly for board game purposes and shall not be taken seriously nor shall it take the place of a qualified medical professionals advice.

SouthernTrendKiller
--KiLLDeviLLPaiN--

PLEASE VISIT-STILL UNDER CONSTRUCTION
www.KILLDEVILL.com
Born again with snakes eyes-becoming god size-I am suicide-I the unlord

[Spook]

We need to move some of these articles to the greatest articles section afte everyone has read them and set them up in sections or updates by subjects. Looks good bro. <img src="http://www.nirvana2.com/smilies/bounce2.gif" alt="Bounce2" width="40" height="62"><!--graemlin::bounce2:-->

*** "I've eaten all my vegetables but I only have one question. Where do I put their wheelchairs when I'm done?" ***

[Cyd]

Author Rea knows his sh..stuff.

"People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf."
--GEORGE ORWELL

[DTD]

After re-reading that, I figured out something...on your slin days you only eat 0.5 g. of carbs per 25 lbs. of bw/day????....Damn, so if I am approx. 250 for arguments sake, then I only intake 10 g. of carbs that entire day???....Wow, that's gonna eliminate any of the protein powders and bars I have, there's carbs in all of 'em...

And the EOD on the susp. and the slin??...I see the reasoning for using the alternation of pathways, but damn, wouldn't most people just use both ED??....

Just queries...Not fairies, Killz...hahahahha....
Hey the shirt looks great, wish I could fill it out....hmmmmm....