GH and Topamax

[barnes3]

I have read the articles in the article section on the use of GH and Slin and T3. But as many of you know I am epileptic and I am currently taking 200mg of Topamax 2xED. As I was reading the articles on Slin some things dawned on me that struck my curiosity. First was that some of the warning signs of hypoglycemia are some of the side of effects of Topamax, in fact alot of the side effects are the same, but they are not cause by the same factor as far as from what I have read so far. The two main ones being tingling sensations of the hands and feet and drowsiness. My doctor told me that I would be losing alot of weight due to the Topamax but I never thought anything of it until now. I have only begun to read some reasearch cases on it. They are hard to find because Topamax is a relatively new drug and the all around effects are still being discovered from what I have read so far.
But what I am trying to connect here is the possibility of substituting Topamax for Slin on a milder basis. I know that the effects and gains would not be as great as that if one would to use Slin, but for someone that has epilepcy, bipolar disease, severe migraine, or anyone else that is prescribed to this medicine it could be beneficial to their use without using slin.
My THEORY is that Topamax, once digested, is processed by the liver thus releasing the neccessary IGF-1 that would else be neccessary for use with GH. As far as how it acts in the similar properties as slin once in the blood stream I am still trying to find. I do believe it to act in similar ways to that because I have had a very good diet for the past 5 months while they have increased my dosages on Topamax (no alcohol for 5 months) and I have lost BF and gain a good bit of lean body mass within that 5 months. More so than I did the previous 5 months when I wasn't taking any medication. But it is a start on something that I thought might be beneficial to me and people like me.

I am in now way saying that everything is write, and this is an open discusion for criticism and direction if any.

peace.
barnes3

"Real Leaders are ordinary People with Extraordinary Determination"

[This message was edited by barnes3 on 05-08-03 at 02:11 PM.]

[barnes3]

AAN: Topiramate Shows Promise in Patients with Diabetes and Metabolic Syndrome
By Jill Stein

HONOLULU, HI -- April 2, 2003 -- Topiramate, an anti-epileptic drug, has favorable weight and metabolic profile which makes it a useful agent for treatment of diabetic, overweight patients with diabetic neuropathy, according to a placebo controlled, randomized trial.

The effects of anti-epileptic drugs on diabetic metabolic parameters have not been widely reported, according to Dr. Martina Bebin, from University of Alabama in Huntsville. Dr. Bebin presented the findings here April 1st at the 55th Annual Meeting of the American Academy of Neurology.

With colleagues, she analyzed pooled metabolic data in nearly 900 diabetic patients with peripheral polyneuropathic pain, who were treated with topiramate in three double-blind, placebo-controlled studies.

The trial included patients 18 to 75 years of age who had painful diabetic peripheral polyneuropathy for at least 6 months and a hemoglobin A1c level less than 11% for at least 3 months before randomization.

After a baseline period of up to 28 days, subjects were randomized to treatment with topiramate 100, 200, or 400 mg/day, or placebo. The duration of double-blind treatment was 18 to 22 weeks.

Diabetic control (hemoglobin A1C levels) improved significantly during topiramate treatment, and the effect was dose-related, Dr. Bebin said. Most patients had clinically significant decreases in hemoglobin A1C greater than 0.5%. Reductions in hemoglobin A1C did not seem to correlate with topiramate-induced weight loss.

The study also found that most patients lost weight during topiramate treatment. Eighteen to 40% of patients showed clinically significant weight loss, losing at least 5% of their baseline weight. The effect was dose-related.

Reports of hypoglycemia and hypoglycemic reactions were similar for topiramate and placebo. Adverse events that led to dose reduction, interruption of therapy, or discontinuation of treatment, were dose-related and similar to observations in double-blind trials of topiramate as monotherapy in other populations (for example, epilepsy patients).

Johnson& Johnson Pharmaceutical Research & Development sponsored this study.


[Study title: Topiramate in Diabetic Patients: Effect on Diabetic Control and Weight. Abstract: P01.097]

If I understand that last part correctly, this is seems to show that how insulin and topamax react in the body a similar.
barnes3

"Real Leaders are ordinary People with Extraordinary Determination"

[barnes3]

to the average person...

You can get it prescribed to you for "migraines" <hint hint> <img src="http://www.massmonsters.com/infopop/emoticons/icon_wink.gif" alt="Wink" width="15" height="15"><!--graemlin:--> If this turns out to be a good thing. All the studys that I have read have said that adults should not take dosages of 200mg at one time because some of the other side effects become more dramatic such as memory difficulties and blurred vision. And what I mean by dramatic is that they will last longer than they would normally than usually would if you were to take them at a normal dosage.

barnes3

"Real Leaders are ordinary People with Extraordinary Determination"

[barnes3]

Found the mechanisms on the nervous system, and I thought that it may have some impact on something. I am having a hard time piecing where they would fit as far as others.

Spook...Rj420... Mr.X...STK... maybe one of you guys could piece this piece of info as to how it would work on the muscles??
"MECHANISM OF ACTION

Although the exact mechanism of action is unknown, laboratory studies suggest that TOPAMAX works in three ways to calm the activity of nerve cells and reduce seizure frequency. It:

Decreases nerve-cell excitation by blocking certain neurotransmitters from binding to glutamate receptors in the brain.
Enhances the activity of GABA (gamma-aminobutyric acid), a neurotransmitter that inhibits nerve-cell excitation in the brain.
Blocks sodium channels, thus decreasing excessive nerve-cell firing."
-http://www.topamax.com/about/fact_sheet.htm


Thanks
barnes3

"Real Leaders are ordinary People with Extraordinary Determination"

[barnes3]

that this is not been approach well, and I apologize to everyone...I have this problem of thinking through my problems to come to a solution... and I did not make my objective very clear to begin with.

Once I find a way to phrase my objective correctly so that everyone can understand my jibberish and incoherant thought process' I will post that.

barnes3

"Real Leaders are ordinary People with Extraordinary Determination"

in the meantime I'll read through some stuff and see if anything stands out for your purposes.

[barnes3]

<BLOCKQUOTE class="ip-ubbcode-quote"><font size="-1">quote:</font><HR>Originally posted by rj420:
in the meantime I'll read through some stuff and see if anything stands out for your purposes.[/quote]

I think that the only way that I will really be able to prove that anything will really be able to work with this is to actually go through with it, keep a really detail journail on weight, bf%, diet, calorie intake, servings of food, etc. along with blood work by a doctor(have to find one). Then come to some conclusion with all my findings. I really do think that GH and Topamax will come around to be a good combination in my situation and for other people that are prescribed to it or will want to be prescribed to it for their "mirgraines".

As far as Topamax by itself, I will be able to tell everyone what its effects are this summer for a bodybuilder because that is when I will completely drop the Depakote from my system, but in theory I think it will kinda take on a T3 aspect for the fat burning because I haven't lost any muscle mass since I started Topamax, if anything I have gained muscle...thus why I suspect it having some other type of properties.

barnes3

"Real Leaders are ordinary People with Extraordinary Determination"