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Thread: What An Ester Is And How It Works

  1. #1

    Default What An Ester Is And How It Works

    You may have noticed the similarities on the labeling of steroids. Let's look at testosterone for example. One can find compounds like testosterone cypionate, enanthate, propionate, heptylate; caproate, phenylpropionate, isocaproate, decanoate, acetate, the list goes on and on. In all such cases the parent hormone is testosterone, which had been modified by adding an ester (enanthate, propionate etc.) to its structure. The following question arises: What is the difference between the various esterified versions of testosterone in regards to their use in bodybuilding?

    An ester is a chain composed primarily of carbon and hydrogen atoms. This chain is typically attached to the parent steroid hormone at the 17th carbon position (beta orientation), although some compounds do carry esters at position 3 (for the purposes of this article it is not crucial to understand the exact position of the ester). Esterification of an injectable anabolic/androgenic steroid basically accomplishes one thing, it slows the release of the parent steroid from the site of injection. This happens because the ester will notably lower the water solubility of the steroid, and increase its lipid (fat) solubility. This will cause the drug to form a deposit in the muscle tissue, from which it will slowly enter into circulation as it is picked up in small quantities by the blood. Generally, the longer the ester chain, the lower the water solubility of the compound, and the longer it will take to for the full dosage to reach general circulation.

    Slowing the release of the parent steroid is a great benefit, as free testosterone (or other steroid hormones) would remain active in the body for a very short period of time (typically hours). This would necessitate a daily injection schedule if one wished to maintain a continuous elevation of testosterone. By adding an ester, injections can be as infrequent as once per week. Without the use of an ester, maintaining consistant blood levels with an injectable anabolic/androgen would be much more difficult.

    Esterification temporarily deactivates the steroid molecule. With a chain blocking the 17th beta position, binding to the androgen receptor is not possible (it can exert no activity in the body). In order for the compound to become active the ester must therefore first be removed. This automatically occurs once the compound has filtered into blood circulation, where esterase enzymes quickly cleave off (hydrolyze) the ester chain. This will restore the necessary hydroxyl (OH) group at the 17th beta position, enabling the drug to attach to the appropriate receptor. Now and only now will the steroid be able to have an effect on skeletal muscle tissue.

    You can start to see why considering testosterone cypionate more potent than enanthate makes little sense, as your muscles are seeing only free testosterone no matter what ester was used to deploy it.

    ACTIONS OF DIFFERENT ESTERS

    There are many different esters that are used with anabolic/androgenic steroids, but again, they all do basically the same thing. Esters vary only in their ability to reduce a steroid's water solubility. An ester like propionate for example will slow the release of a steroid for a few days, while the duration will be up to 15 days+/- with a decanoate ester. Esters have no effect on the tendency for the parent steroid to convert to estrogen or DHT (dihydrotestosterone: a more potent metabolite) nor will it effect the overall muscle-building potency of the compound. Any differences in results and side effects that may be noted by bodybuilders who have used various esterified versions of the same base steroid are just issues of timing. Given an equal blood level of testosterone, there would be no difference in the rate of aromatization or DHT conversion between different esters. There is simply no mechanism for this to be possible.

    There is however one way that we can say an ester does technically effect potency; it is calculated in the steroid weight. The heavier the ester chain, the greater is its percentage of the total weight. In the case of testosterone enanthate for example, 250mg of esterified steroid (testosterone enanthate) is equal to only 180mg of free testosterone. 70mgs out of each 250mg injection is the weight of the ester. If we wanted to be really picky, we could consider enanthate slightly MORE potent than cypionate (I know this goes against popular thinking) as its ester chain contains one less carbon atom (therefore taking up a slightly smaller percentage of total weight). Propionate would of course come out on top of the three, releasing a measurable (but not significant) amount more testosterone per injection than cypionate or enanthate.

    So,esters do not alter the activity of the parent steroid in any way other than to delay its release. In the end,testosterone is testosterone.

  2. #2

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    ESTER PROFILES

    Sustanon:
    The four different testosterone esters in this product certainly look appealing to the consumer, there is no denying that. But for the athlete I think it is all just a matter of marketing (Hell, why buy one ester when you can get four?). If you were undergoing testosterone replacement therapy, you would presumably find Sustanon a much more comfortable option than testosterone enanthate. You would supposedly need to visit the doctor less frequently for an injection, and blood levels would be more steadily maintained between treatments. In the real world, it doesn't quite work like that, but for the bodybuilder who is injecting 4 ampules of Sustanon per week, there is no advantage over other testosterone products. In fact, the high price tag for Sustanon usually makes it a very poor buy in the face of cheaper testosterone enanthate/cypionate. Bodybuilders should probably stop looking at the four ester issue, and stick with totals (Sustanon is just a 250mg testosterone ampule). If you could get nearly double the milligram amount for the same price with enanthate, this is the better product to go with hands down. Leave the high priced stuff for the guys who don't know any better.

    Acetate: Chemical Structure C2H4O2.
    Also referred to as Acetic Acid; Ethylic acid; Vinegar acid; vinegar; Methanecarboxylic acid. Acetate esters delay the release of a steroid for only a couple of days.This ester is used on oral primobolan tablets (metenolone acetate), Finaplix (trenbolone acetate) implant pellets, and occasionally testosterone.

    Propionate: Chemical Structure C3H6O2.
    Also referred to as Carboxyethane; hydroacrylic acid; Methylacetic acid; Ethylformic acid; Ethanecarboxylic acid; metacetonic acid; pseudoacetic acid; Propionic Acid. Propionate esters will slow the release of a steroid for several days. To keep blood levels from fluctuating greatly, propionate compounds are usually injected from every day to three times weekly. Testosterone propionate and methandriol dipropionate (two separate propionate esters attached to the parent steroid methandriol) are popular items.

    Phenylpropionate: Chemical Structure C9H10O2.
    Also referred to as Propionic Acid Phenyl Ester. Phenylpropionate will extend the release of active steroid a few days longer than propionate. To keep blood levels even, injections are given at least twice weekly. Durabolin is the drug most commonly seen with a phenylpropionate ester (nandrolone phenylpropionate), although it is also used with testosterone in Sustanon and Omnadren.

    Isocarpoate: Chemical Structure C6H12O2.
    Also referred to as Isocaproic Acid; isohexanoate; 4-methylvaleric acid. Isocaproate begins to near enanthate in terms of release. The duration is still shorter, with a notable hormone level being sustained for approximately one week. This ester is used with testosterone in the blended products Sustanon and Omnadren.

    Caproate: Chemical Structure C6H12O2.
    Also referred to as Hexanoic acid; hexanoate; n-Caproic Acid; n-Hexoic acid; butylacetic acid; pentiformic acid; pentylformic acid; n-hexylic acid; 1-pentanecarboxylic acid; hexoic acid; 1-hexanoic acid; Hexylic acid; Caproic acid. This ester is identical to isocarpoate in terms of atom count and weight, but is laid out slightly different (Isocaproate has a split configuration, difficult to explain here but easy to see on paper). Release duration would be very similar to isocaproate (levels sustained for approximately one weak), perhaps coming slightly closer to enanthate due to its straight chain. Caproate is the slowest releasing ester used in Omnadren, which is why most athletes notice more water retention with this compound due to blood level saturation.

    Enanthate: Chemical Structure C7H14O2.
    Also referred to as heptanoic acid; enanthic acid; enanthylic acid; heptylic acid; heptoic acid; Oenanthylic acid; Oenanthic acid. Enanthate is one of the most prominent esters used in steroid manufacture (most commonly seen with testosterone but is also used in other compounds like Primobolan Depot). Enanthate will release a steady (yet fluctuating as all esters are) level of hormone for approximately 10-14 days. Although in medicine enanthate compounds are often injected on a bi-weekly or monthly basis, athletes will inject at least weekly to help maintain a uniform blood level.

    Cypionate: Chemical Structure C8H14O2.
    Also referred to as Cyclopentylpropionic acid, cyclopentylpropionate. Cypionate is a very popular ester in the U.S., although it is scarcely found outside this region. Its release duration is almost identical to enanthate (10-14 days), and the two are likewise thought to be interchangeable in U.S. medicine.

    Decanoate: Chemical Structure C10H20O2.
    Also referred to as decanoic acid; capric acid; caprinic acid; decylic acid, Nonanecarboxylic acid. The Decanoate ester is most commonly used with the hormone nandrolone (as in Deca-Durabolin) and is found in virtually all corners of the world. Testosterone decanoate is also the longest acting constituent in Sustanon, greatly extending its release duration. The release time with Decanoate compounds is listed to be as long as one month, although most recently we are finding that levels seem to drop significantly after two weeks. To keep blood levels more uniform, athletes (as they have always known to do) will follow a weekly injection schedule.

    Undecylenate: Chemical Structure C11H20O2.
    Also referred to as Undecylenic acid; Hendecenoic acid; Undecenoic acid. This ester is very similar to decanoate, containing only one carbon atom more. Its release duration is likewise very similar (approximately 2-3 weeks), perhaps extending a day or so past that seen with decanoate. Undecylenate seems to be exclusive to the veterinary preparation Equipoise (boldenone undecylenate), although there is no reason it would not work well in human-use preparations (Equipoise certainly works fine for athletes). Again, weekly injections are most common.

    Undecanoate: Chemical Structure C11H22O2.
    Also referred to as Undecanoic Acid; 1-Decanecarboxylic acid; Hendecanoic acid; Undecylic acid. Undecanoate is not a commonly found ester, and only appears to be used in the nandrolone preparation Dynabolan, and oral testosterone undecanoate (Andriol). Since this ester is chemically very similar to undecylenate (it is only 2 hydrogen atoms larger), it has a similar release duration (approximately 2-3 weeks). Although this ester is used in the oral preparation Andriol, there is no reason to believe it carries any properties unique of other esters. Andriol in fact works very poorly at delivering testosterone, bolstering the idea that oral administration is not the idea use of esterified androgens.

    Laurate: Chemical structure C12H24O2.
    Also referred to as Dodecanoic acid, laurostearic acid, duodecyclic acid, 1-undecanecarboxylic acid, and dodecoic acid. Laurate is the longest releasing ester used in commercial steroid production, although longer acting esters do exist. Its release duration would be closer to one month than the other esters listed above, although realistically we are probably to expect a notable drop in hormone level after the third week. Laurate is exclusively found in the veterinary nandrolone preparation Laurabolin, perhaps seen as slightly advantageous over a decanoate ester due to a less frequent injection schedule. Again athletes will most commonly inject this drug weekly, no doubt in part due to its low strength (25mg/ml or 50mg/ml).

  3. #3

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    brilliant! helps alot
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  4. #4

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    i allways wondered at times about the means of a longer ester in the enethate compound
    Quote Originally Posted by Bufbiker View Post
    I think everyone should have steroids while they're on sex.

    THIS SITE IS FOR EDUCATIONAL PURPOSES THEREIN. PLEASE READ THE RULES AND NO SOURCE CHECKS.

    Height: 5' 9''
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  5. #5

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    Excellent post!!!
    i knew alot of this but not in the words you put it in

    I do have one question,although im not sure if you would know the answer.

    What exactly is the type of ester in boldernone?

    i know eq was made to try and create a injectable dianobol,but with the the ester attached to dianobol its given a slow released effect so therefor it dosent act like dianobol.so its as if they have attached a longer releasing ester to it,or is it a shorter ester that hasnt exactly worked rite.
    this is something that has been ticking on my mind for ages,with alot of research i have still found nothing!
    so if this question makes sense,could you shed some light in for me
    Last edited by Dleato; 07-10-2010 at 06:21 AM. Reason: cause im cool

  6. #6

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    To create EQ they took dbol, added a double bond between carbon atoms 1 and 2, and in the case of Boldenone Undeclynate, estrified it. Though in addition to the Undeclynate version, there is also Boldenone Propionate, as well as Boldenone No Ester. It is the double bond between carbon atoms 1 and 2 on the Dianobol steran nucleus that makes it Boldenone, not the ester or lack thereof. This 1-2 double bond dramatically slows the rate of conversion to estrogen.

    Undecylenate: Chemical Structure C11H20O2.
    Also referred to as Undecylenic acid; Hendecenoic acid; Undecenoic acid. This ester is very similar to decanoate, containing only one carbon atom more. Its release duration is likewise very similar (approximately 2-3 weeks), perhaps extending a day or so past that seen with decanoate. Undecylenate seems to be exclusive to the veterinary preparation Equipoise (boldenone undecylenate), although there is no reason it would not work well in human-use preparations

  7. #7
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    So with a long esther test if you took one shot and that was it, how long would the test be at full value in your system? 48 hours? damn i took an ambien tooo sooom ill get back to this in th morning

  8. #8

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    The answer to that is explained here... http://forums.isteroids.com/anabolic...s-ais-pct.html

    Though the half life and active life aren't synonymous. The half life is how long it takes to halve the serum concentration and active life refers to how long you'd have a large enough amount to exert an effect or to inhibit a response.

  9. #9
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    Great threads SYL thanks for these. Its for information such as this that I originally joined this forum.

  10. #10
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    Excellent informative stuff, well worth the read..!

    Thanks SYL
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